Endocrine Abstracts

Previous studies have demonstrated that POMC peptides are present in islets of Langerhans and suggested that ACTH-related peptides may act as paracrine modulators of insulin secretion. In order to shed light on the cellular mechanisms involved in these responses, we have carried out experiments using the MIN6 mouse insulinoma cell-line and synthetic ACTH 1-24. Following the detection of mouse ACTH receptor (MC-2) receptor mRNA by PCR amplification of MIN6 cDNA, perifusion expe...